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The Organic Chemistry of Biological Pathways, by John McMurry, Begley Tadhg
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Intended for advanced undergraduates and graduate students in all areas of biochemistry, The Organic Chemistry of Biological Pathways provides an accurate treatment of the major biochemical pathways from the perspective of mechanistic organic chemistry.
- Sales Rank: #198825 in Books
- Brand: Brand: Roberts and Company Publishers
- Published on: 2005-02
- Original language: English
- Number of items: 1
- Dimensions: 7.50" h x 1.30" w x 9.40" l, 3.33 pounds
- Binding: Hardcover
- 512 pages
- Used Book in Good Condition
Review
"The book's greatest strength is its emphasis on the conceptual unity of organic chemistry and biochemistry. The chemical structures are presented with great care and accompanied by lucid explanations." —Charles Clapp, Bucknell University
"This textbook elegantly portrays the complementary nature of chemistry and biology. By describing biological processes in detailed chemical terms, the authors have provided a resource that provides an unparalleled look into the fascinating and emerging field of chemical biology." —Hung-wen Liu, University of Texas
"This textbook satisfies a major need in chemistry curricula, bridging the gap between introductory organic chemistry and biochemistry/biology. It is the first book written for students that presents biological transformations from the perspective of organic mechanism. The book significantly augments modern biochemistry curricula and may catalyze a resurgence of interest in biological mechanism." —Carolyn R. Bertozzi, University of California, Berkeley
About the Author
John E. McMurry received his B.A. from Harvard University and his Ph.D. at Columbia University. Dr. McMurry is a Fellow of the American Association for the Advancement of Science, and an Alfred P. Sloan Research Foundation Fellow. He has received several awards, which include the National Institutes of Health Career Development Award, the Alexander von Humboldt Senior Scientist Award, and the Max Planck Research Award. In addition to The Organic Chemistry of Biological Pathways, he is also the author of Organic Chemistry, Fundamentals of Organic Chemistry, and Chemistry (with Robert Fay).
Tadhg P. Begley received his B.Sc. from National University of Ireland and his Ph.D. at the California Institute of Technology. Dr. Begley is the recipient of many awards, including the Merck Faculty Development Award and the Camille and Henry Dreyfus Teacher-Scholar Award. His research group uses the principles and techniques of organic chemistry to study complex organic transformations found in vitamin biosynthetic pathways. In addition to The Organic Chemistry of Biological Pathways, Dr. Begley has edited Cofactor Biosynthesis: A Mechanistic Perspective.
Most helpful customer reviews
7 of 8 people found the following review helpful.
Useful, but somewhat disappointing
By Austin Hudson-Lapore
When I opened the book for the first time, my immediate reaction was "Wow, there's not much text, is there?" The page is fairly small to begin with, the font is fairly large, the line spacing and margins are generous, and there are a lot of figures. I realized after a while that this wasn't an especially fair criticism, though. Because the purpose of the text is primarily to show mechanisms of important metabolic reactions, most of the information can be conveyed through chemical structures. In fact, a significant chunk of the text is devoted to saying (paraphrased), "well, it's extremely difficult to determine exact mechanisms, so the precise path that this reaction follows is uncertain. The figure shows the most commonly proposed mechanism, but another possibility is that..." The alternative is most often explained in words but sometimes gets its own figure.
The book is very descriptive, offering mostly "what" and "how" rather than "why." Arguably, there's nothing inherently wrong with that, especially because the preface essentially says directly that that's the purpose of the book. But it does mean that the book is quite limited, and isn't very useful on its own. You would need a fully fleshed-out course to extract much value from it, and unfortunately, I know from firsthand experience that a well-designed course is far from a given. Our lectures and exams basically just asked us to regurgitate the mechanisms from the text, which was not useful or enjoyable. That seems to be the danger: a lazy lecturer told to use this textbook to teach a course will produce a worthless class from which the students will take away almost nothing of lasting value.
All that aside, there are still some quibbles with the book. Some of the figures are repetitious, which can be quite confusing. And it doesn't cover some extremely important mechanisms, such as THF-mediated methylation.
It's frustrating, honestly - even if you have no problem with the book's purpose as a compilation of reaction mechanisms, you would then expect it to be an excellent reference... and it just isn't. There are too many gaps in what it covers, and too many things that are annoyingly difficult to find among the thicket of chemical structures. It certainly still has its uses, considering that there's really no other textbook with such an authoritative compilation of mechanistic detail on the topics it does cover. But there seems to be room for it to be so much better, and its uses are limited at any rate.
4 of 4 people found the following review helpful.
Great book
By Meagan
This is a very easy to read book. If you have already taken organic chemistry it may be a bit of a review but it does apply the information to biological pathways. If you have not already taken organic chemistry, it is a great book to learn it. I think that it is easier, yet just as comprehensive as other textbooks out there, but it skips over things that are more useful in physical organic chemistry (energy equations and things like that). We are using it in our biochemistry class and it's a great review that gets to the point.
5 of 6 people found the following review helpful.
Learn more about biosynthesis of primary and secondary metabolites
By Rob
This book is simply great. The scholar and very clear presentation by the authors make the subject of each chapter almost self-explanatory. The first two chapters introduce the organic reactions which are relevant in biosynthesis, stereochemistry of biological molecules and the major classes of primary metabolites. In the following chapters the authors discuss, with care and in detail, the biosynthesis of every class of primary metabolite, showing mechanisms for every single reaction. The last chapter on biosynthesis presents examples of some natural products biosynthesis (classical examples). Unfortunately, no example on the biosynthesis of phenylpropanoid derivatives is included. However, even though, the book is worth of purchase for students and teachers interested in the mechanistic aspects of primary and secondary metabolites biosynthesis.
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